Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

  title={Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.},
  author={S A Langhans-Rajasekaran and Yihong Wan and Xin Yun Huang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 19},
Tsk/Itk and Btk are members of the pleckstrin-homology (PH) domain-containing tyrosine kinase family. The PH domain has been demonstrated to be able to interact with beta gamma subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) (G beta gamma) and phospholipids. Using cotransfection assays, we show here that the kinase activities of Tsk and Btk are stimulated by certain G beta gamma subunits. Furthermore, using an in vitro reconstitution assay with purified bovine brain… CONTINUE READING

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