Activation of Trk neurotrophin receptors in the absence of neurotrophins.

@article{Lee2001ActivationOT,
  title={Activation of Trk neurotrophin receptors in the absence of neurotrophins.},
  author={Francis B. S. Lee and Moses V Chao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 6},
  pages={3555-60}
}
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades. Here, we describe an approach to use small molecule agonists to transactivate Trk neurotrophin receptors. Activation of TrkA receptors in PC12 cells and TrkB in hippocampal neurons was observed after treatment with adenosine, a neuromodulator that acts… CONTINUE READING
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