Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice

@article{Jie2014ActivationOT,
  title={Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice},
  author={Pinghui Jie and Zihong Lu and Zhiwen Hong and Lin Li and Libin Zhou and Yingchun Li and Rong Zhou and Yebo Zhou and Yimei Du and Lei Chen and Ling Chen},
  journal={Molecular Neurobiology},
  year={2014},
  volume={53},
  pages={8-17}
}
Transient receptor potential vanilloid 4 (TRPV4) is widely expressed in the central nervous system and can be activated by multiple stimuli during cerebral ischemia. Recently, we reported that intracerebroventricular (icv.) injection of HC-067047, a specific TRPV4 antagonist, reduced brain infarction following 60-min of middle cerebral artery occlusion (MCAO). This study was undertaken to investigate the molecular mechanisms underlying TRPV4-mediated neuronal injury in cerebral ischemia. We… CONTINUE READING