Activation of Transforming Growth Factor β by Malaria Parasite-derived Metalloproteinases and a Thrombospondin-like Molecule

@article{Omer2003ActivationOT,
  title={Activation of Transforming Growth Factor β by Malaria Parasite-derived Metalloproteinases and a Thrombospondin-like Molecule},
  author={Fakhreldin Mohamed Omer and Juliana Barcellos de Souza and Patrick H. Corran and Ali A Sultan and Eleanor M. Riley},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={1817 - 1827}
}
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite. The antiinflammatory cytokine transforming growth factor (TGF)-beta plays a crucial role in preventing the severe pathology of malaria in mice and TGF-beta production is associated with reduced risk of clinical malaria in humans. Here we show that serum-free preparations of Plasmodium… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Similar Papers

Loading similar papers…