Activation of Toll-like receptor 3 inhibits Marek’s disease virus infection in chicken embryo fibroblast cells

@article{Hu2015ActivationOT,
  title={Activation of Toll-like receptor 3 inhibits Marek’s disease virus infection in chicken embryo fibroblast cells},
  author={Xuming Hu and Haitao Zou and Aijian Qin and Kun Qian and Hong-xia Shao and Jianqiang Ye},
  journal={Archives of Virology},
  year={2015},
  volume={161},
  pages={521-528}
}
Toll-like receptor 3 (TLR3) is a critical component of the innate immune system against viral infection and controls the activation of adaptive immunity. The role of TLR3 in Marek’s disease virus (MDV) infection is not clear. In this study, we found that the abundance of TLR3 mRNA was significantly higher in chicken embryo fibroblast cells (CEF) infected with MDV than in a control group. Activated TLR3 signaling via TLR3 ligand stimulation inhibited replication of the RB1B strain of MDV in CEF… CONTINUE READING
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