Activation of The Apical Na + / H + Exchanger NHE 3 By Formate : A Basis of Enhanced Fluid and Electrolyte Reabsorption By Formate in the Kidney Proximal Tubule

@inproceedings{Petrovic2004ActivationOT,
  title={Activation of The Apical Na + / H + Exchanger NHE 3 By Formate : A Basis of Enhanced Fluid and Electrolyte Reabsorption By Formate in the Kidney Proximal Tubule},
  author={Snezana Petrovic and Sharon Barone and Alan M. Weinstein and Manoocher Soleimani},
  year={2004}
}
Formate stimulates sodium chloride and fluid reabsorption in kidney proximal tubule, however, the exact cellular mechanism of this effect remains unknown. We hypothesized that the primary target of formate is the apical Na/H exchanger. Here we demonstrate that formate directly enhances the apical Na/H exchanger (NHE3) activity in mouse kidney proximal… CONTINUE READING