Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia

@inproceedings{Talbot2011ActivationOT,
  title={Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia},
  author={S{\'e}bastien Talbot and Jenny Pena Dias and Karim Lahjouji and Maur{\'i}cio Reis Bogo and Maria M Campos and P. Gaudreau and R{\'e}jean Couture},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
The kinin B1 receptor (B1R) is upregulated by pro-inflammatory cytokines and oxydative stress, which are enhanced by transient receptor potential vanilloid subtype 1 (TRPV1) activation. To examine the link between TRPV1 and B1R in inflammatory pain, this study aimed to determine the ability of TRPV1 to regulate microglial B1R expression in the spinal cord dorsal horn, and the underlying mechanism. B1R expression (mRNA, protein and binding sites) was measured in cervical, thoracic and lumbar… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 1991
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