Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells.

@article{Bardell2010ActivationOT,
  title={Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells.},
  author={Tamera K Bardell and Eric L. Barker},
  journal={Neurochemistry international},
  year={2010},
  volume={57 1},
  pages={76-83}
}
Calcium influx activates biosynthesis of the endogenous cannabinoids 2-arachidonyl glycerol (2-AG) and anandamide (AEA). The calcium channel involved with endocannabinoid synthesis and release in neurons is still unknown. The canonical TRP (TRPC) channels are calcium-permeable channels that are a homology-based subdivision of the broader class of TRP channels. TRPC3, 6, and 7 are G-protein-gated non-selective cation channels that have been localized to lipid rafts and shown to colocalize with… CONTINUE READING

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