Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).

@article{Niforatos2007ActivationOT,
  title={Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).},
  author={Wende Niforatos and Xu-feng Zhang and Marc R Lake and Karl A. Walter and Torben R. Neelands and Thomas F. Holzman and Victoria E. S. Scott and Connie R. Faltynek and Robert B. Moreland and Jun Chen},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 5},
  pages={1209-16}
}
As a member of the transient receptor potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in nociceptive function and pain states. The endogenous ligands that activate TRPA1 remain unknown. However, various agonists have been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent natural products [e.g., allyl isothiocyanate (ITC), cinnamaldehyde, allicin, and gingerol]. In general, these agents are either highly… CONTINUE READING

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