Activation of TREK-1 by morphine results in analgesia without adverse side effects.

  title={Activation of TREK-1 by morphine results in analgesia without adverse side effects.},
  author={Ma{\"i}ly Devilliers and J{\'e}r{\^o}me Busserolles and St{\'e}phane Lolignier and Emmanuel Deval and Vanessa Pereira and Abdelkrim Alloui and Marine Christin and Bruno Mazet and Patrick Delmas and Jacques Noel and Michel Lazdunski and Alain Eschalier},
  journal={Nature communications},
Morphine is the gold-standard pain reliever for severe acute or chronic pain but it also produces adverse side effects that can alter the quality of life of patients and, in some rare cases, jeopardize the vital prognosis. Morphine elicits both therapeutic and adverse effects primarily through the same μ opioid receptor subtype, which makes it difficult to separate the two types of effects. Here we show that beneficial and deleterious effects of morphine are mediated through different… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS
13 Citations
73 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 73 references

Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon

  • V Gil
  • Am. J. Physiol. Gastrointest. Liver Physiol. 303,
  • 2012

Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated mu opioid receptor (MOR-1) splice variants

  • S Majumdar
  • J. Med. Chem
  • 2012

Similar Papers

Loading similar papers…