Activation of TLR3 in the trophoblast is associated with preterm delivery.

  title={Activation of TLR3 in the trophoblast is associated with preterm delivery.},
  author={Kaori Koga and Ingrid Cardenas and Paulomi Bole Aldo and Vikki M Abrahams and Bing Peng and Sara Fill and Roberto Romero and Gil Mor},
  journal={American journal of reproductive immunology},
  volume={61 3},
PROBLEM Toll-like receptors (TLRs) recognize conserved sequences on the surface of pathogens and trigger effector cell functions. Previously, we described the expression of TLR3 by human trophoblast and their ability to respond to (Poly[I:C]). Here we evaluate the effect of Poly[I:C] on mouse pregnancy and characterize the local and systemic response. METHOD OF STUDY C57B/6 wild type (wt) and TLR3 knockout (TLR3KO) mice were treated with Poly[I:C] at 16.5 dpc and pregnancy outcome recorded… CONTINUE READING
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