Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro.

@article{Onozawa2012ActivationOT,
  title={Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro.},
  author={Yoshiko Onozawa and Yoshifumi Fujita and Harumi Kuwabara and Miyuki Nagasaki and Tomoaki Komai and Tomiichiro Oda},
  journal={European journal of pharmacology},
  year={2012},
  volume={683 1-3},
  pages={325-31}
}
An orphan G-protein-coupled receptor, T cell death-associated gene 8 (TDAG8) which has been reported to be a proton sensor, inhibits the production of pro-inflammatory cytokines induced by extracellular acidification. Recently, we have found that TDAG8 knockout mice showed significant exacerbation in various immune-mediated inflammation disease models. To elucidate the role of TDAG8, we screened an in-house library to find compounds which have a profile as a TDAG8 agonist using a cyclic… CONTINUE READING

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