Activation of Sterol-Responsive Element Binding Proteins in a Sucrose- Induced Model of Lysosomal Storage

@article{Beersel2013ActivationOS,
  title={Activation of Sterol-Responsive Element Binding Proteins in a Sucrose- Induced Model of Lysosomal Storage},
  author={Guillaume Van Beersel and Michel Jadot and Isabelle Hamer and Thierry Arnould},
  journal={The Open Pathology Journal},
  year={2013},
  volume={7},
  pages={16-27}
}
The accumulation of pinocytosed sucrose in lysosomes constitutes a convenient means to mimic a lysosomal storage and to study how such storage impacts the biology of the organelle and beyond. Several reports have shown that lysosomal storages can perturb the redistribution of lysosomal lipids, cholesterol in particular. Our goal was to analyse the effect of the intralysosomal accumulation of sucrose on the transcription factors Sterol Regulatory Element Binding Proteins (SREBPs): key actors of… 

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