Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein.

@article{Chung2004ActivationOS,
  title={Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein.},
  author={Y K Chung and Nam-Hyuk Cho and Maria Ines Garcia and S Lee and Pinghui Feng and Jae U Jung},
  journal={Journal of virology},
  year={2004},
  volume={78 12},
  pages={6489-97}
}
The saimiri transforming protein (STP) oncogene of Herpesvirus saimiri subgroup A strain 11 (STP-A11) is not required for viral replication but is required for lymphoid cell immortalization in culture and lymphoma induction in primates. We previously showed that STP-A11 interacts with cellular Src kinase through its SH2 binding motif and that this interaction elicits Src signal transduction. Here we demonstrate that STP-A11 interacts with signal transducer and activator of transcription 3… CONTINUE READING