Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2

@article{Steinman2003ActivationOS,
  title={Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2},
  author={Richard A. Steinman and Abbey Lynn Wentzel and Yalin Lu and Christine J Stehle and Jennifer R Grandis},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={3608-3615}
}
The signal transducing protein Stat3 activates gene transcription in cells in response to multiple cytokines. Constitutive activation of Stat3 has been observed in solid tumors including head and neck squamous cell carcinoma. Stat3 activation in cancer has been associated with autocrine stimulatory loops and is believed to convey a growth advantage to cells. We now demonstrate ligand-independent activation of Stat3 by high cell density in multiple cancer cell lines. Activation of Stat3 is… CONTINUE READING
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Showing 1-10 of 10 references

Annu

  • H Yasukawa, A Sasaki, A. Yoshimura
  • Rev. Immunol., 18, 143–164.
  • 2000
Highly Influential
8 Excerpts

Cytokine Growth Factor Rev

  • K Takeda, S. Akira
  • 2000
Highly Influential
3 Excerpts

Am

  • D Giri, M Ozen, M. Ittmann
  • J. Pathol., 159, 2159–2165.
  • 2001
1 Excerpt

J

  • B Xie, J Zhao, +4 authors XY. Fu
  • Biol. Chem., 276, 19512–19523.
  • 2001

Mol

  • BB Yaroslavskiy, DB Stolz, SC Watkins, SM Alber, NA Bradbury, RA. Steinman
  • Med., 7, 49–58.
  • 2001
1 Excerpt

Adv

  • RS Chapman, P Lourenco, +6 authors CJ. Watson
  • Exp. Med. Biol., 480, 129–138.
  • 2000
1 Excerpt

Biochem

  • A Junicho, T Matsuda, +5 authors A. Muraguchi
  • Biophys. Res. Commun., 278, 9–13.
  • 2000
3 Excerpts

Proc

  • JR Grandis, SD Drenning, +7 authors JD. Kim
  • Natl. Acad. Sci. USA, 97, 4227–4232.
  • 2000

Int

  • MT Dimanche-Boitrel, O Micheau, +4 authors E. Solary
  • J. Cancer,
  • 1998

Nat

  • SF.
  • Med., 4, 1449–1452. Sehgal PB, Guo GG, Shah M…
  • 1998

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