Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection.

Abstract

Urocortin is a 40 amino acid peptide of the corticotrophin-releasing factor (CRF) family that is synthesized and released by cardiac myocytes. Endogenous urocortin expression is increased during ischemia/reperfusion (I/R) and addition of exogenous urocortin reduces cell death caused by I/R injury. Studies have also showed that the protective action of… (More)
DOI: 10.1016/j.mce.2010.04.013

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Cite this paper

@article{Yuan2010ActivationOS, title={Activation of Src protein tyrosine kinase plays an essential role in urocortin-mediated cardioprotection.}, author={Zhaokan Yuan and Roy B. McCauley and Carol A Chen-Scarabelli and Kadija Abounit and Anastasis Stephanou and Se{\'a}n Pio Barry and Richard Austen Knight and Samuel F Saravolatz and Louis D. Saravolatz and Berkin O Ulgen and Gabriele M Scarabelli and Giuseppe Faggian and Alessandro Mazzucco and Tiziano Maria Scarabelli}, journal={Molecular and cellular endocrinology}, year={2010}, volume={325 1-2}, pages={1-7} }