Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders.

@article{Ayli2008ActivationOS,
  title={Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders.},
  author={Elias E Ayli and Weijie Li and Tamu T. Brown and Agnieszka W Witkiewicz and Rosalie Elenitsas and John T Seykora},
  journal={Journal of cutaneous pathology},
  year={2008},
  volume={35 3},
  pages={
          273-7
        }
}
BACKGROUND Src-family tyrosine kinases (SFKs) are important regulators of keratinocyte growth and differentiation. In a broad range of cell types, persistent activation of SFKs correlates with increased cell proliferation. In this study, we determined if SFK activity is increased in cutaneous neoplasia and psoriasis, common hyperproliferative epidermal disorders. METHODS Formalin-fixed tissue sections of unremarkable epidermis, psoriasis, actinic keratoses (AKs), squamous cell carcinoma in… CONTINUE READING

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