Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains.

@article{Katagiri1999ActivationOS,
  title={Activation of Src family kinase yes induced by Shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains.},
  author={Yohko U. Katagiri and Toshiyuki Mori and Hideki Nakajima and Chiaki Katagiri and Tomoko Taguchi and Tae Takeda and Nobutaka Kiyokawa and Junichiro Fujimoto},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 49},
  pages={35278-82}
}
Shiga toxin (Stx) is an enterotoxin produced by Shigella dysenteriae serotype 1 and enterohemorrhagic Escherichia coli, which binds specifically to globotriaosylceramide, Gb3, on the cell surface and causes cell death. We previously demonstrated that Stx induced apoptosis in human renal tubular cell line ACHN cells (Taguchi, T., Uchida, H., Kiyokawa, N., Mori, T., Sato, N., Horie, H., Takeda, T and Fujimoto, J. (1998) Kidney Int. 53, 1681-1688). To study the early signal transduction after Stx… CONTINUE READING

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