Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.

@article{AriasRomero2009ActivationOS,
  title={Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells.},
  author={Luis Enrique Arias-Romero and Sayanti Saha and Olga Villamar-Cruz and S. Yip and Stephen P Ethier and Zhong-Yin Zhang and Jonathan Chernoff},
  journal={Cancer research},
  year={2009},
  volume={69 11},
  pages={4582-8}
}
Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but the mechanism underlying this effect has been unclear. Using human breast epithelial cells grown in a three-dimensional matrix, we found that PTP1B, but not the closely related enzyme T-cell PTP, is required for ErbB2 transformation in vitro. Activation of… CONTINUE READING
34 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…