Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1.

@article{Yamada2011ActivationOS,
  title={Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1.},
  author={O. Yamada and Kohji Ozaki and Thoru Furukawa and Mitsuyo Machida and Yan-Hua Wang and Toshiko Motoji and Tsuyoshi Mitsuishi and Masaharu Akiyama and Hisashi Yamada and Kiyotaka Kawauchi and Rumiko Matsuoka},
  journal={Cellular signalling},
  year={2011},
  volume={23 7},
  pages={
          1119-27
        }
}
We used two imatinib resistant cell lines, K562-ADM cells, which over-express P-glycoprotein (a product of the ABCB1 gene, more commonly known as MDR1), and K562-hTERT cells, which over-express the telomerase reverse transcriptase (TERT), as models to show that the acquisition of multidrug resistance in CML is associated with the enhanced phosphorylation of signal transducer and activator of transcription 5 (STAT5). The induction of P-glycoprotein expression that occurred in response to… CONTINUE READING
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