Activation of STAT1 is required for interferon-alpha-mediated cell death.

Abstract

Interferon-alpha (IFNα)-induced cell death of tumor cells is likely mediated through several signaling pathways. We previously demonstrated that blocking the activation of phosphoinositide-3-kinase, PI3K, or mammalian target of rapamycin, mTOR, partially inhibited apoptosis induced by IFNα. Here, we postulate using pharmacological inhibition and dominant… (More)
DOI: 10.1016/j.yexcr.2010.10.002

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@article{Arulampalam2011ActivationOS, title={Activation of STAT1 is required for interferon-alpha-mediated cell death.}, author={Velmurugesan Arulampalam and Iryna Kolosenko and Linn Hjortsberg and A Bj{\"o}rklund and Dan Grand{\'e}r and Katja Pokrovskaja Tamm}, journal={Experimental cell research}, year={2011}, volume={317 1}, pages={9-19} }