Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.

@article{Yang2016ActivationOS,
  title={Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.},
  author={Yanqin Yang and Wenwen Wang and Zhewen Xiong and Jiamin Kong and Yuwen Qiu and Feihai Shen and Zhiying Huang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2016},
  volume={34},
  pages={128-37}
}
Triptolide (TP), an active component of the traditional Chinese herb Tripterygium wilfordii Hook f. (TWHF), has multiple pharmacological effects. However, the severe toxicity of TP greatly restricts its clinical applications. Although TP exposure causes serious heart injury, the mechanism underlying TP-induced cardiotoxicity has rarely been investigated. In previous studies, we found that TP-induced oxidative stress was involved in the mitochondria-dependent apoptosis of cardiomyocytes. Opening… CONTINUE READING

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