Activation of SHIP via a small molecule agonist kills multiple myeloma cells.

  title={Activation of SHIP via a small molecule agonist kills multiple myeloma cells.},
  author={Michael Kennah and Tien Yin Yau and Matt Nodwell and Gerald Krystal and Raymond J Andersen and Christopher J Ong and Alice L-F Mui},
  journal={Experimental hematology},
  volume={37 11},
OBJECTIVE Multiple myeloma (MM) is a B-lymphocyte neoplasia that is presently incurable because the tumor cells become resistant to currently available drugs. The growth and survival signals resulting from interactions between the malignant clones and the bone marrow microenvironment are mediated chiefly through the phosphoinositide 3'-kinase/Akt kinase signaling pathway. Thus agents that can abrogate this pathway have great potential as targeted therapies. A novel approach in this regard is… CONTINUE READING


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