Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.

@article{Coutinho2017ActivationOS,
  title={Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.},
  author={Eulalia A. Coutinho and Shiki Okamoto and Ayako Wendy Ishikawa and Shigefumi Yokota and Nobuhiro Wada and Takahiro Hirabayashi and Kumiko Saito and Tatsuya Sato and Kazuyo Takagi and Chen-Chi Wang and Kazuto Kobayashi and Yoshihiro Ogawa and Seiji Shioda and Yumiko Yoshimura and Yasuhiko Minokoshi},
  journal={Diabetes},
  year={2017},
  volume={66 9},
  pages={2372-2386}
}
The ventromedial hypothalamus (VMH) regulates glucose and energy metabolism in mammals. Optogenetic stimulation of VMH neurons that express steroidogenic factor 1 (SF1) induces hyperglycemia. However, leptin acting via the VMH stimulates whole-body glucose utilization and insulin sensitivity in some peripheral tissues, and this effect of leptin appears to be mediated by SF1 neurons. We examined the effects of activation of SF1 neurons with DREADD (designer receptors exclusively activated by… CONTINUE READING
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