Activation of Rho in the injured axons following spinal cord injury.

@article{Madura2004ActivationOR,
  title={Activation of Rho in the injured axons following spinal cord injury.},
  author={Tomas Madura and Toshihide Yamashita and Tateki Kubo and Masashi Fujitani and Ko Hosokawa and Masaya Tohyama},
  journal={EMBO reports},
  year={2004},
  volume={5 4},
  pages={
          412-7
        }
}
Axons of the adult central nervous system have very limited ability to regenerate after injury. This inability may be, at least partly, attributable to myelin-derived proteins, such as myelin-associated glycoprotein, Nogo and oligodendrocyte myelin glycoprotein. Recent evidence suggests that these proteins inhibit neurite outgrowth by activation of Rho through the neurotrophin receptor p75(NTR)/Nogo receptor complex. Despite rapidly growing knowledge on these signals at the molecular level, it… CONTINUE READING

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