Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity.

@article{Xu2017ActivationOR,
  title={Activation of Renal (Pro)Renin Receptor Contributes to High Fructose-Induced Salt Sensitivity.},
  author={Chuanming Xu and Aihua Lu and Xiaohan Lu and Linlin Zhang and Hui Fang and Li Yan Zhou and Tianxin Yang},
  journal={Hypertension},
  year={2017},
  volume={69 2},
  pages={339-348}
}
A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying mechanism largely remains unknown. The major goal of the present study was to test the role of renal (pro)renin receptor (PRR) in this model. In Sprague-Dawley rats, high-fructose intake increased renal expression of full-length PRR, which were attenuated by allopurinol. High-fructose intake also upregulated renal mRNA and protein expression of sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter, as well… CONTINUE READING
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