Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.

Abstract

The Ras signaling pathway plays a critical role in B lymphocyte development and activation, but its activation mechanism has not been well understood. At least one mode of Ras regulation in B cells involves a Ras-guanyl nucleotide exchange factor, RasGRP3. We demonstrate here that RasGRP3 undergoes phosphorylation at Thr-133 upon B cell receptor cross… (More)

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@article{Aiba2004ActivationOR, title={Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.}, author={Yuichi Aiba and Masatsugu Oh-hora and Shigeki Kiyonaka and Yayoi Kimura and Atsushi Hijikata and Yasuo Mori and Tomohiro Kurosaki}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2004}, volume={101 47}, pages={16612-7} }