Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast.

@article{Dejean2002ActivationOR,
  title={Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast.},
  author={Laurent Dejean and Bertrand Beauvoit and Odile Bunoust and Bernard Gu{\'e}rin and Michel Rigoulet},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={293 5},
  pages={1383-8}
}
We investigated the effects of genetic and physiological modulations of the cAMP-protein kinase A pathway on mitochondrial biogenesis of yeast cells grown on lactate. Yeast mutants with over-activated Ras/adenylate cyclase pathway (i.e., Ras2(val19), ira1Delta(ira2)Delta) or with a constitutive downstream activation of protein kinases A (i.e., bcyDelta) showed an increase in the mitochondrial enzyme content. In contrast, loss of Ras activity (i.e., Ras2 mutant) resulted in a slight decrease… CONTINUE READING

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