Activation of Rap1 promotes prostate cancer metastasis.

  title={Activation of Rap1 promotes prostate cancer metastasis.},
  author={Candice L. Bailey and Patrick Kelly and Patrick J. Casey},
  journal={Cancer research},
  volume={69 12},
Elucidating the mechanisms of prostate cancer (CaP) survival and metastasis are critical to the discovery of novel therapeutic targets. The monomeric G protein Rap1 has been implicated in cancer tumorigenesis. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting Rap1 may promote several processes associated with cancer cell metastasis. Examination of CaP cell lines revealed cells with a high metastatic ability exhibited increased Rap1 activity and reduced… CONTINUE READING
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