Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans.

@article{Hope2008ActivationOR,
  title={Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans.},
  author={Hannah Hope and St{\'e}phanie Bogliolo and Robert A Arkowitz and Martine Bassilana},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 9},
  pages={
          3638-51
        }
}
Rho G proteins and their regulators are critical for cytoskeleton organization and cell morphology in all eukaryotes. In the opportunistic pathogen Candida albicans, the Rho G proteins Cdc42 and Rac1 are required for the switch from budding to filamentous growth in response to different stimuli. We show that Dck1, a protein with homology to the Ced-5, Dock180, myoblast city family of guanine nucleotide exchange factors, is necessary for filamentous growth in solid media, similar to Rac1. Our… CONTINUE READING
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Candida albicans development. Eukaryot

  • M. 321–329. Bassilana, J. Blyth, R. A. Arkowitz
  • Eukaryot. Cell
  • 2003
Highly Influential
13 Excerpts

Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, NY: Cold Spring Harbor

  • E. Harlow, D. Lane
  • 1988
Highly Influential
3 Excerpts

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