Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.

@article{Li2016ActivationOR,
  title={Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.},
  author={Yize Li and Shuvojit Banerjee and Yuyan Wang and Stephen A. Goldstein and Beihua Dong and Christina A Gaughan and Robert H. Silverman and Susan R Weiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 8},
  pages={2241-6}
}
The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS. Although all three enzymatically active OAS proteins in humans--OAS1, OAS2, and OAS3--synthesize 2-5A upon binding dsRNA, it is unclear which are responsible for RNase L activation during viral infection. We used clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein-9 nuclease (Cas9) technology to… CONTINUE READING
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