Activation of Protein Serine/Threonine Phosphatase PP2Cα Efficiently Prevents Liver Fibrosis

@article{Wang2010ActivationOP,
  title={Activation of Protein Serine/Threonine Phosphatase PP2C$\alpha$ Efficiently Prevents Liver Fibrosis},
  author={Lirui Wang and Xu Wang and J. Chen and Z. Yang and Liang Yu and Li-hong Hu and Xu Shen},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
Background Over-activation of TGFβ signaling pathway and uncontrolled cell proliferation of hepatic stellate cells (HSCs) play pivotal roles in liver fibrogenesis, while the protein serine/threonine phosphatase PP2Cα was reported to negatively regulate TGFβ signaling pathway and cell cycle. Our study aimed to investigate the role of PP2Cα in liver fibrogenesis. Methodology/Principal Findings The effects of PP2Cα activation on liver fibrosis were investigated in human HSCs and primary rat HSCs… Expand
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