Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.

@article{Dude2009ActivationOP,
  title={Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.},
  author={Carolynn M. Dude and C-Y Kelly Kuan and James R Bradshaw and Nicholas D. E. Greene and Fr{\'e}d{\'e}ric Relaix and Michael R. Stark and Clare V. H. Baker},
  journal={Developmental biology},
  year={2009},
  volume={326 2},
  pages={314-26}
}
Vertebrate cranial neurogenic placodes are relatively simple model systems for investigating the control of sensory neurogenesis. The ophthalmic trigeminal (opV) placode, for which the earliest specific marker is the paired domain homeodomain transcription factor Pax3, forms cutaneous sensory neurons in the ophthalmic lobe of the trigeminal ganglion. We previously showed that Pax3 expression in avian opV placode cells correlates with specification and commitment to a Pax3+, cutaneous sensory… CONTINUE READING
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