Activation of PPARgamma increases PTEN expression in pancreatic cancer cells.

@article{Farrow2003ActivationOP,
  title={Activation of PPARgamma increases PTEN expression in pancreatic cancer cells.},
  author={Buckminster J Farrow and Bernard Mark Evers},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={301 1},
  pages={50-3}
}
The PI3K pathway contributes to the invasive properties and apoptosis resistance that epitomize pancreatic cancers. PPARgamma is a ligand-activated transcription factor with anti-inflammatory and anti-tumor effects; the mechanisms of tumor suppression are unknown. The purpose of this study was to examine whether activation of PPARgamma can increase the expression of the tumor suppressor PTEN and inhibit PI3K activity. AsPC-1 human pancreatic cancer cells, transfected with a PPRE-luciferase… CONTINUE READING