• Medicine
  • Published in
    European journal of…
    2009

Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.

@article{Knig2009ActivationOP,
  title={Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.},
  author={Bettina K{\"o}nig and Alexander M. Koch and Julia Spielmann and Christian Hilgenfeld and Frank Hirche and Gabriele I. Stangl and Klaus Eder},
  journal={European journal of pharmacology},
  year={2009},
  volume={605 1-3},
  pages={
          23-30
        }
}
Fibrates and thiazolidinediones, agonists of PPARalpha and PPARgamma, respectively, reduce triglyceride concentrations in rat liver and plasma. Fatty acid and triacylglycerol synthesis in mammals is regulated by sterol regulatory element-binding protein (SREBP)-1c. Recently, it was shown that insulin-induced gene (Insig)-1, the key regulator of SREBP activity, is up-regulated by both activation of PPARalpha and PPARgamma. In order to elucidate whether inhibition of SREBP-1 activation may… CONTINUE READING

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