Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.

@article{Paintlia2010ActivationOP,
  title={Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.},
  author={Ajaib Singh Paintlia and Manjeet Kaur Paintlia and Avtar Kaur Singh and John K. Orak and Inderjit Singh},
  journal={Glia},
  year={2010},
  volume={58 14},
  pages={1669-85}
}
Previously, we and others documented that statins including-lovastatin (LOV) promote the differentiation of oligodendrocyte progenitor cells (OPCs) and remyelination in experimental autoimmune encephalomyelitis (EAE), an multiple sclerosis (MS) model. Conversely, some recent studies demonstrated that statins negatively influence oligodendrocyte (OL) differentiation in vitro and remyelination in a cuprizone-CNS demyelinating model. Therefore, herein, we first investigated the cause of impaired… CONTINUE READING

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