Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence

@inproceedings{Jin2016ActivationOP,
  title={Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence},
  author={Huanhuan Jin and Naqi Lian and Fengxiang Zhang and Lulu Chen and Quan Chen and Chunhua Lu and Mianli Bian and Jiaofang Shao and Lin Wu and Shizhong Zheng},
  booktitle={Cell Death and Disease},
  year={2016}
}
Activation of quiescent hepatic stellate cells (HSCs) is the major event in hepatic fibrogenesis, along with enhancement of cell proliferation and overproduction of extracellular matrix. Although inhibition of cell proliferation and induction of apoptosis are potential strategies to block the activation of HSCs, a better understanding of the senescence of activated HSCs can provide a new therapeutic strategy for prevention and treatment of liver fibrosis. The antioxidant curcumin, a… CONTINUE READING