Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver.

@article{Zabielski2010ActivationOP,
  title={Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver.},
  author={Piotr Zabielski and Agnieszka U Blachnio-Zabielska and M Baranowski and Malgorzata Zendzian-Piotrowska and J. Cristopher Gorski},
  journal={Prostaglandins & other lipid mediators},
  year={2010},
  volume={93 3-4},
  pages={120-5}
}
Serine palmitoyltransferase (SPT) is a key enzyme in de novo sphingolipid biosynthesis. SPT activity in liver is up-regulated by pro-inflammatory cytokines, which play an important role in initiation of liver regeneration after partial hepatectomy (PH). The aim of the study was to investigate the impact of a high-fat diet or PPARα activation by bezafibrate on the activity and protein expression of SPT in rat liver after PH. The animals were divided into three groups: those fed a standard chow… CONTINUE READING

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