Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.

@article{Yamatani1990ActivationOP,
  title={Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.},
  author={Toshiyuki Yamatani and Atsushi D Yamaguchi and Akio Nakamura and Tetsuo Morishita and Seizo Kadowaki and Toshiro Fujita and Tsutomu Chiba},
  journal={The American journal of physiology},
  year={1990},
  volume={259 1 Pt 1},
  pages={E73-9}
}
An investigation was done to elucidate the regulatory role of protein kinase C (PKC) in insulin release and also the effects of PKC activation on NaF-induced inositol phospholipid (PI) turnover in and insulin release from rat insulinoma cells (RINr). NaF stimulated insulin secretion in association with an increase in [3H]inositol phosphate formation in RINr cells. Furthermore, NaF induced a rapid decrease in 32P-labeling of phosphatidylinositol-4,5-diphosphate (PIP2) with a concomitant increase… CONTINUE READING