Activation of PI3K signaling in Merkel cell carcinoma.

@article{Nardi2012ActivationOP,
  title={Activation of PI3K signaling in Merkel cell carcinoma.},
  author={Valentina Nardi and Youngchul Song and Juan A. Santamaria-Barria and Arjola K. Cosper and Quynh T Lam and Anthony C Faber and Genevieve Marie Boland and Beow Yong Yeap and Kristin E Bergethon and Vanessa L. Scialabba and Hensin Tsao and Jeffrey Settleman and David P. Ryan and Darrell R. Borger and Atul K. Bhan and Mai M P Hoang and Anthony John Iafrate and James C. Cusack and Jeffrey A. Engelman and Dora C Dias-Santagata},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 5},
  pages={1227-36}
}
PURPOSE Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still unknown, we hypothesized that deregulation of signaling pathways commonly activated in cancer may contribute to MCC tumorigenesis and may provide insights into targeted therapy approaches for this malignancy. EXPERIMENTAL DESIGN We retrospectively profiled 60 primary MCC samples… CONTINUE READING

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Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2011
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