Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

@inproceedings{McBride2009ActivationOP,
  title={Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival},
  author={Sean M. J. McBride and Daniel A Perez and Mei-Yin C Polley and Scott R. Vandenberg and Justin S. Smith and Shichun Zheng and Kathleen R. Lamborn and John K. Wiencke and Susan M. Chang and Michael D. Prados and Mitchel S. Berger and David Stokoe and Daphne Adele Haas-Kogan},
  booktitle={Journal of Neuro-Oncology},
  year={2009}
}
Recent evidence suggests the Akt-mTOR pathway may play a role in development of low-grade gliomas (LGG). We sought to evaluate whether activation of this pathway correlates with survival in LGG by examining expression patterns of proteins within this pathway. Forty-five LGG tumor specimens from newly diagnosed patients were analyzed for methylation of the putative 5′-promoter region of PTEN using methylation-specific PCR as well as phosphorylation of S6 and PRAS40 and expression of PTEN protein… CONTINUE READING