Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

@article{Man2003ActivationOP,
  title={Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons},
  author={H. Man and Qinhua Wang and W. Lu and W. Ju and G. Ahmadian and Lidong Liu and S. D'Souza and T. Wong and C. Taghibiglou and Jie Lu and L. Becker and L. Pei and Fang Liu and M. Wymann and J. Macdonald and Y. Wang},
  journal={Neuron},
  year={2003},
  volume={38},
  pages={611-624}
}
Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at activated synapses. Increased insertion of postsynaptic alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (AMPARs) appears to be crucial for CA1 LTP. However, the mechanism underlying AMPAR insertion during LTP remains largely unknown. We now report that phosphatidylinositol 3-kinase (PI3K) is complexed with AMPARs at synapses and activated by selective stimulation of synaptic N-methyl-D… Expand
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