Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons
@article{Man2003ActivationOP, title={Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons}, author={Heng-Ye Man and Qinhua Wang and Wei-yang Lu and William H. Ju and Gholamreza Ahmadian and Lidong Liu and Sandra D'Souza and Tak Pan Wong and Changiz Taghibiglou and Jie Lu and Laurence E. Becker and Lin Pei and Fang Liu and Matthias P. Wymann and John F. Macdonald and Yu Tian Wang}, journal={Neuron}, year={2003}, volume={38}, pages={611-624} }
342 Citations
Ca2+ Permeable AMPA Receptor Induced Long-Term Potentiation Requires PI3/MAP Kinases but Not Ca/CaM-Dependent Kinase II
- BiologyPloS one
- 2009
The results suggest that distinct synaptic signaling underlies GluR2-lacking CP-AMPAR-dependent LTP, and reinforces the recent notions that CP-ampARs are important facilitators of synaptic plasticity in the brain.
Control of Cerebellar Long-Term Potentiation by P-Rex-Family Guanine-Nucleotide Exchange Factors and Phosphoinositide 3-Kinase
- BiologyPloS one
- 2010
It is found that LTP evoked at parallel fibre synapses by 1 Hz stimulation or by NO donors was not sustained beyond 30 min when P-Rex was eliminated or Rac inhibited, suggesting that cerebellar LTP exhibits a late phase analogous to hippocampal LTP.
AMPA receptor trafficking: a road map for synaptic plasticity.
- BiologyMolecular interventions
- 2003
The molecular and cellular mechanisms that regulate each of these processes, and their importance for synaptic plasticity, are now starting to be unraveled.
Phosphatidylinositol 3 Kinase Activation and AMPA Receptor Subunit Trafficking Underlie the Potentiation of Miniature EPSC Amplitudes Triggered by the Activation of L-Type Calcium Channels
- BiologyThe Journal of Neuroscience
- 2006
The data are consistent with the notion that PI3 kinase and membrane fusion/trafficking events play a pivotal role in coordinating changes in synaptic strength, mediated by AMPA receptors, which are triggered by alterations in postsynaptic calcium concentrations whether these changes are initiated via NMDar-dependent or NMDAR-independent routes.
Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1
- Biology, ChemistryNeuron
- 2006
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP
- Biology, ChemistryThe EMBO journal
- 2013
It is concluded that PKCλ is the critical signalling molecule responsible for GluA1‐containing AMPAR phosphorylation and synaptic incorporation at activated synapses during LTP expression.
Glutamate Activates Protein Kinase B (PKB/Akt) through AMPA Receptors in Cultured Bergmann Glia Cells
- Biology, ChemistryNeurochemical Research
- 2005
An augmentation in protein kinase B phosphorylation and activity after glutamate exposure is demonstrated, independent of Ca2+ influx, but sensitive to Src blockers.
BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation
- BiologyNature Neuroscience
- 2007
It is shown that the N-methyl-D-aspartate receptor, NMDAR, brain-derived neurotrophic factor, postsynaptic density protein 95 (PSD-95), and phosphatidylinositol 3-kinase are involved in a single pathway for synaptic potentiation.
Membrane insertion of new AMPA receptors and LTP induced by glycine is prevented by blocking NR2A-containing NMDA receptors in the rat visual cortex in vitro.
- BiologyCurrent neurovascular research
- 2013
The results suggest that the glycine-induced LTP in layer II/III pyramidal neurons of the rat visual cortex is NMDA-R-dependent and requires NR2A-containing NMda-Rs, not NR2B-containingNMDA-Rs.
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