Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

Heng-Ye Man, Qinhua Wang, +13 authors Yu Tian Wang
Published 2003 in Neuron

Abstract

Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at activated synapses. Increased insertion of postsynaptic alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (AMPARs) appears to be crucial for CA1 LTP. However, the mechanism underlying AMPAR insertion during LTP remains largely unknown. We now report that… (More)

DOI: 10.1016/S0896-6273(03)00228-9

C. H. Lin, S. H. Yeh, K. T. Lu, T. H. Leu, W. C. Chang, P. W. Gean
Neuron
2001

Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

Abstract

8 Figures and Tables

Topics

Cited By

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References

Interaction with the NMDA receptor locks CaMKII in an active conformation

Organization and regulation of proteins at synapses.

Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors.

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.

A role for the PI - 3 kinase signaling pathway in term depression requires postsynaptic clathrin - mediated endocyto

AMPA Receptor Trafficking and the Control of Synaptic Transmission

Coupling of agonist-induced AMPA receptor internalization with receptor recycling.

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.

PDZ domains and the organization of supramolecular complexes.

Presentations referencing similar topics

Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

Abstract

8 Figures and Tables

Topics

Cited By

Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.

Caffeine‐mediated BDNF release regulates long‐term synaptic plasticity through activation of IRS2 signaling

The Activity-Induced Long Non-Coding RNA Meg3 Modulates AMPA Receptor Surface Expression in Primary Cortical Neurons

Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease.

Dual or multi-targeting inhibitors: The next generation anticancer agents.

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

AMPA Receptor Trafficking in Natural and Pathological Aging

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

References

Interaction with the NMDA receptor locks CaMKII in an active conformation

Organization and regulation of proteins at synapses.

Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors.

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.

A role for the PI - 3 kinase signaling pathway in term depression requires postsynaptic clathrin - mediated endocyto

AMPA Receptor Trafficking and the Control of Synaptic Transmission

Coupling of agonist-induced AMPA receptor internalization with receptor recycling.

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.

PDZ domains and the organization of supramolecular complexes.

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