Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1.

@article{Lamphere1994ActivationOP,
  title={Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1.},
  author={Lou Lamphere and Christopher L. Carpenter and Zu-Hang Sheng and Roland G. Kallen and Gustav E. Lienhard},
  journal={The American journal of physiology},
  year={1994},
  volume={266 3 Pt 1},
  pages={E486-94}
}
Insulin treatment of adipocytes causes the rapid phosphorylation of the insulin receptor substrate-1 (IRS-1) on tyrosine. The phosphotyrosine [Tyr(P)] form of IRS-1 then complexes with the enzyme phosphatidylinositol (PI) 3-kinase. In this study, we have investigated the effect of this association on PI 3-kinase activity in 3T3-L1 adipocytes. Insulin… CONTINUE READING