Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury.

@article{Sen2017ActivationOP,
  title={Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury.},
  author={Tanusree Sen and Rajaneesh Gupta and Helen Kaiser and Nilkantha Sen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2017},
  volume={37 24},
  pages={5900-5911}
}
The PKR-like ER kinase (PERK), a transmembrane protein, resides in the endoplasmic reticulum (ER). Its activation serves as a key sensor of ER stress, which has been implicated in traumatic brain injury (TBI). The loss of memory is one of the most common symptoms after TBI, but the precise role of PERK activation in memory impairment after TBI has not been well elucidated. Here, we have shown that blocking the activation of PERK using GSK2656157 prevents the loss of dendritic spines and rescues… CONTINUE READING
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