Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.

@article{Armstrong2009ActivationOP,
  title={Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.},
  author={Souzan Armstrong and Alexey Pereverzev and S. Jeffrey Dixon and Stephen Michael Sims},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 1},
  pages={136-44}
}
Nucleotides, released in response to mechanical or inflammatory stimuli, signal through P2 nucleotide receptors in many cell types. Osteoclasts express P2X7 receptors (encoded by P2rx7) - Ca(2+)-permeable channels that are activated by high concentrations of extracellular ATP. Genetic disruption of P2rx7 leads to increased resorption and reduced skeletal response to mechanical stimuli. To investigate whether P2X7 receptors couple to activation of protein kinase C (PKC), RAW 264.7 cells were… CONTINUE READING

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P 2 nucleotide receptor signaling in osteoclasts

  • J. Korcok, S. M. Sims, S. J. Dixon
  • Nucleotides and Regulation of Bone Cell Function
  • 2007
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