Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

@inproceedings{Lee2012ActivationOP,
  title={Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection},
  author={Benjamin Hoyoung Lee and D. M. Hwang and Nades Palaniyar and Sergio Grinstein and Dana J Philpott and Jim Hu},
  booktitle={PloS one},
  year={2012}
}
Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral vectors can induce systemic inflammatory responses. Indeed, overactive host innate immune responses to viral vectors have led to devastating consequences. Macrophages are important innate immune cells that recognize viruses and induce inflammatory responses at the early stage of infection. However, tissue resident macrophages are not easily activated by the mere presence… CONTINUE READING

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