Activation of P2X receptors induces apoptosis in human retinal pigment epithelium.

@article{Yang2011ActivationOP,
  title={Activation of P2X receptors induces apoptosis in human retinal pigment epithelium.},
  author={Dongli Yang and Susan G. Elner and Andrea J. Clark and Bret A Hughes and Howard R. Petty and Victor M. Elner},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 3},
  pages={1522-30}
}
PURPOSE The retinal pigment epithelium (RPE) is considered a primary site of pathology in age-related macular degeneration (AMD), which is the most prevalent form of irreversible blindness worldwide in the elderly population. Extracellular adenosine triphosphate (ATP) acts as a key signaling molecule in numerous cellular processes, including cell death. The purpose of this study was to determine whether extracellular ATP induces apoptosis in cultured human RPE. METHODS RPE apoptosis was… CONTINUE READING

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