Activation of P-type calcium channel regulates a unique thapsigargin-sensitive calcium pool in embryonic motoneurons.

@article{Scamps2004ActivationOP,
  title={Activation of P-type calcium channel regulates a unique thapsigargin-sensitive calcium pool in embryonic motoneurons.},
  author={Fr{\'e}d{\'e}rique Scamps and Anne Roig and Hassan Boukhaddaoui and Sylvain Andr{\'e} and Sylvie Puech and Jean Valmier},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 4},
  pages={977-82}
}
By regulating voltage-dependent Ca2+ influx and intracellular Ca2+ homeostasis, electrical activity plays a central role in motoneuron development. Dissociated cultures of purified embryonic rat motoneurons were used to explore the molecular mechanisms by which Ca2+ influx control [Ca2+]i transients in these neurons. Thapsigargin (250 nm) and cyclopiazonic acid (10 micro m), which deplete Ca2+ stores in the endoplasmic reticulum, decrease by 30% the depolarization-induced [Ca2+]i transients in… CONTINUE READING