Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol.

@article{Peng2015ActivationON,
  title={Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol.},
  author={Shoujiao Peng and Juan Yao and Yaping Liu and Dongzhu Duan and Xiaolong Zhang and Jianguo Fang},
  journal={Food & function},
  year={2015},
  volume={6 8},
  pages={
          2813-23
        }
}
Natural compounds containing phenoxyl groups and/or Michael acceptor units appear to possess antioxidant and cytoprotective properties. The ginger principal constituent 6-shogaol (6-S) represents one of such compounds. In this study, we reported that 6-S efficiently scavenges various free radicals in vitro, and displays remarkable cytoprotection against oxidative stress-induced cell damage in the neuron-like rat pheochromocytoma cell line, PC12 cells. Pretreatment of PC12 cells with 6-S… CONTINUE READING
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