Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.


OBJECTIVE Proinflammatory mediators influence atherosclerosis by inducing adhesion molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries including p38 MAP kinase. Regions of arteries exposed to high shear stress are protected from inflammation and atherosclerosis, whereas low-shear regions are susceptible. Here we investigated… (More)
DOI: 10.1161/ATVBAHA.109.193375


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